반응 #815356

반응 방정식

potassium carbonate

7-methylimidazo[1,2-a]pyridin-2-ylmethanethiol

5-bromomethyl-2-(N-ethylformamido)benzoxazole

acetone

→

benzoxazole

수율 125.4%

용매

water

반응 조건

후처리

1. 1
   온도cooling
2. 2
   여과the isolated precipitate was collected by filtration

실험 절차

A mixture of 7-methylimidazo[1,2-a]pyridin-2-ylmethanethiol (1.5 g) and 5-bromomethyl-2-(N-ethylformamido)benzoxazole (2.9 g) in a solution of acetone (40 ml) and water (30 ml) was adjusted to pH 9-10 with saturated aqueous potassium carbonate solution under ice-cooling. The mixture was stirred for 2 hours at the same temperature and the isolated precipitate was collected by filtration to give 2-(N-ethylformamido)-5-(7-methylimidazo[1,2-a]pyridin-2-yl)methylthiomethyl]benzoxazole (1.53 g).

출처