반응 #8149

반응 방정식

2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

ethylamine

→

2-(ethylamino)-4-(3-diethylamino-1-propoxy)nitrobenzene

수율 88.0%

용매

THF

반응 조건

후처리

1. 1
   기타After completion of the reaction
2. 2
   농축the reaction mixture is concentrated in vacuo
3. 3
   workup.DISSOLUTIONThe residue is redissolved in EtOAc (10 mL)
4. 4
   세척washed with saturated sodium bicarbonate solution, water, and brine
5. 5
   건조The organic phase is then dried over sodium sulfate
6. 6
   기타the solvent is removed in vacuo

실험 절차

A solution of 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene (2 mmol; preparation described in Example 5) in THF (5 mL) is treated with ethylamine (4 mmol) at rt. After completion of the reaction, the reaction mixture is concentrated in vacuo. The residue is redissolved in EtOAc (10 mL), washed with saturated sodium bicarbonate solution, water, and brine. The organic phase is then dried over sodium sulfate and the solvent is removed in vacuo to afford the product, 2-(ethylamino)-4-(3-diethylamino-1-propoxy)nitrobenzene (520 mg) which was used for further transformation without further purification.

출처