반응 #8146

반응 방정식

nitro

2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

ammonium carbonate

EtOAc

→

2-nitro-5-(3-diethylamino-1-propoxy)aniline

용매

DMF

반응 조건

후처리

1. 1
   세척The combined organic layers are then washed with water and brine
2. 2
   건조dried over Na2SO4
3. 3
   기타Removal of the solvent in vacuo

실험 절차

The nitro compound obtained as above (1.5 mmol) is dissolved in DMF (4 mL) and added with ammonium carbonate (500 mg). The reaction mixture is then heated at 80° C. for 48 h. EtOAc (2×10 mL). The combined organic layers are then washed with water and brine and dried over Na2SO4. Removal of the solvent in vacuo yielded the 2-nitro-5-(3-diethylamino-1-propoxy)aniline (300 mg) which is used for further transformation without any purification.

출처