반응 #814371

반응 방정식

8-trimethylsilylethynyl-1,4-dioxaspiro[4.5]decane

potassium carbonate

→

8-ethynyl-1,4-dioxaspiro[4.5]decane

용매

methanol

반응 조건

후처리

1. 1
   농축The reaction mixture is then concentrated under reduced pressure to a residue
2. 2
   workup.STIRRINGThe residue is stirred in about 150 mL of water
3. 3
   추출the mixture is extracted with three 150 mL portions of diethyl ether
4. 4
   건조The combined extracts are dried with magnesium sulfate
5. 5
   여과filtered
6. 6
   농축The filtrate is concentrated under reduced pressure

실험 절차

A mixture of 16.7 grams (0.07 mole) of 8-trimethylsilylethynyl-1,4-dioxaspiro[4.5]decane and 1.1 grams (0.07 mole) of potassium carbonate in 200 mL of methanol is stirred at ambient temperature for about one hour. The reaction mixture is then concentrated under reduced pressure to a residue. The residue is stirred in about 150 mL of water, and the mixture is extracted with three 150 mL portions of diethyl ether. The combined extracts are dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure, yielding 8-ethynyl-1,4-dioxaspiro[4.5]decane.

출처