반응 #81364

반응 방정식

N-(1,1-Dimethylethoxycarbonyl)phenylalanine

dicyclohexylcarbodiimide

pentafluorophenol

→

N-(1,1-dimethylethoxycarbonyl)phenylalanine pentafluorophenyl ester

수율 99.7%

용매

ethyl acetate

ethyl acetate

반응 조건

후처리

1. 1
   여과The suspension was filtered
2. 2
   기타the solvent was evaporated under reduced pressure from the filtrate
3. 3
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate
4. 4
   여과The suspension was filtered
5. 5
   기타the solvent was evaporated under reduced pressure from the filtrate

실험 절차

N-(1,1-Dimethylethoxycarbonyl)phenylalanine (6.36 g, 24 mmol) in ethyl acetate (50 mL) at 0° C. was added to dicyclohexylcarbodiimide (4.95 g, 24 mmol) and pentafluorophenol (4.42 g, 24 mmol) in ethyl acetate (50 mL) at 0° C. The mixture was stirred for 2.75 h at 0° C. The suspension was filtered and the solvent was evaporated under reduced pressure from the filtrate. The residue was dissolved in ethyl acetate. The suspension was filtered and the solvent was evaporated under reduced pressure from the filtrate to give N-(1,1-dimethylethoxycarbonyl)phenylalanine pentafluorophenyl ester (10.32 g, quantitative).

출처