반응 #81270

반응 방정식

methyl 4-(1-hydroxy-1-methylethyl)-2-methoxymethyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

sodium hydroxide

→

title compound

수율 75.4%

4-(1-Hydroxy-1-methylethyl)-2-methoxymethyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acid

수율 75.4%

반응 조건

후처리

1. 1
   여과At the end of this time, the insoluble matter was filtered off
2. 2
   workup.ADDITION4 ml of a 1N aqueous solution of hydrochloric acid were added to the filtrate
3. 3
   여과The resulting crystalline powder was then collected by filtration

실험 절차

A solution of 462 mg of methyl 4-(1-hydroxy-1-methylethyl)-2-methoxymethyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in Example 82(b)] in 4 ml of a 1N aqueous solution of sodium hydroxide was stirred at room temperature for 5 hours. At the end of this time, the insoluble matter was filtered off, and 4 ml of a 1N aqueous solution of hydrochloric acid were added to the filtrate. The resulting crystalline powder was then collected by filtration, to give 338 mg of the title compound, melting at 187° C. (with decomposition at 192°-195° C.).

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