반응 #812501

반응 방정식

4-hydroxy-5-methoxy-isophthalaldehyde

hydrobromic acid

→

4,5-dihydroxyisophthalaldehyde

용매

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도under reflux
3. 3
   workup.ADDITIONare added
4. 4
   여과the separated precipitate is filtered under suction
5. 5
   세척washed with water
6. 6
   여과filtered over 50 g of aluminum oxide (activity grade The crystalline material
7. 7
   기타obtained
8. 8
   기타is recrystallized from ethyl acetate/n-hexane

실험 절차

5.0 g of 4-hydroxy-5-methoxy-isophthalaldehyde are treated with 50 ml of constant-boiling hydrobromic acid and heated to boiling under reflux and while stirring under an argon atmosphere for 3 hours. After cooling 50 ml of ice-water are added thereto, and the separated precipitate is filtered under suction and washed with water. The crude product is taken up in ethyl acetate and filtered over 50 g of aluminum oxide (activity grade The crystalline material obtained is recrystallized from ethyl acetate/n-hexane. There is obtained 4,5-dihydroxyisophthalaldehyde in the form of slightly orange crystals of m.p. 201°-202°.

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