반응 #812357

반응 방정식

2-aminoethoxyamine dihydrochloride

(1S,3aS,5S,7aR)-1-formyl-5-phenyl -7a-methylperhydroinden-3a-ol

Na2CO3

HCl

sodium acetate

→

title compound

수율 69.4%

(1S,3aS,5S,7aR)-1-[(E)-2-Aminoethoxyimino]methyl-5-phenyl-7a-methylperhydroinden-3a-ol

수율 69.4%

용매

dioxane

water

dioxane

water

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   건조The organic layer was dried over anhydrous sodium sulfate
3. 3
   기타evaporated to dryness

실험 절차

To a solution of 6.30 g of 0.12 g of 2-aminoethoxyamine dihydrochloride, 0.28 g of sodium acetate in 2 ml of dioxane and 1 ml of water was made aid to pH 4.5 with 3N HCl. A solution of 0.20 g of (1S,3aS,5S,7aR)-1-formyl-5-phenyl -7a-methylperhydroinden-3a-ol in 1 ml of dioxane and 0.5 ml of water was added dropwise at room temperature. After 1 hr the solution was alkalinized with 10% aqueous Na2CO3 and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and evaporated to dryness. The crude product was ground with diethyl ether to give 0.17 g of the title compound (I-am) as a white solid.

출처