반응 #81178

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5-cyano-4-(1-hydroxy-1-methylpropyl)-2-propylimidazole

sodium hydride

4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide

→

title compound

수율 77.4%

5-Cyano-4-(1-hydroxy-1-methylpropyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole

수율 77.4%

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실험 절차

Following a procedure a similar to that described in Example 18(a), but using 380 mg of 5-cyano-4-(1-hydroxy-1-methylpropyl)-2-propylimidazole (prepared as described in Preparation 20), 88 mg of sodium hydride (as a 55% w/w dispersion in mineral oil) and 1.07 g of 4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide, 0.97 g of the title compound were obtained as an amorphous solid.

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