반응 #81175

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2-butyl-5-cyano-4-(1-hydroxy-1-methylpropyl)imidazole

sodium hydride

4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide

→

title compound

수율 72.0%

2-Butyl-5-cyano-4-(1-hydroxy-1-methylpropyl)-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole

수율 72.0%

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실험 절차

Following a procedure similar to that described in Example 18(a), but using 465 mg of 2-butyl-5-cyano-4-(1-hydroxy-1-methylpropyl)imidazole (prepared as described in Preparation 19), 92 mg of sodium hydride (as a 55% w/w dispersion in mineral oil) and 1.11 g of 4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide, 1.00 g of the title compound was obtained as a gum.

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