반응 #81172

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ethyl 2-butyl-4-(1-ethyl-1-hydroxypropyl)imidazole-5-carboxylate

sodium hydride

4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide

→

title compound

수율 52.1%

Ethyl 2-butyl-4-(1-ethyl-1-hydroxypropyl)-1-{4 -[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

수율 52.1%

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실험 절차

Following a procedure similar to that described in Example 18(a), but using 0.75 g of ethyl 2-butyl-4-(1-ethyl-1-hydroxypropyl)imidazole-5-carboxylate (prepared as described in Preparation 13), 0.12 g of sodium hydride (as a 55% w/w dispersion in mineral oil) and 1.51 g of 4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide, there were obtained 1.05 g of the title compound as an amorphous solid.

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