반응 #811037

반응 방정식

butyl (5R)-3-[3,5-difluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinecarboxylate

methylamine

→

title compound

(5R)-(−)-N-Methyl-3-[3,5-difluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinecarboxamide

용매

MeOH

반응 조건

후처리

1. 1
   농축concentrated under reduced pressure
2. 2
   기타The residue is purified by radial chromatography [4000 micron silica gel rotor; MeOH/CH2Cl2 (3/97) eluent]

실험 절차

The butyl (5R)-3-[3,5-difluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinecarboxylate (EXAMPLE 17, Step 1) is treated with 2M methylamine in MeOH (0.1 M in starting material), and the reaction mixture is stirred at ambient temperature for 30 mins and then concentrated under reduced pressure. The residue is purified by radial chromatography [4000 micron silica gel rotor; MeOH/CH2Cl2 (3/97) eluent] to give the title compound, mp 179–181° C.; MS (ESI+) for C15H17N3O4F2 m/z 342 (M+H)+; [α]25D−40 (c 0.95, DMSO).

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