반응 #811018

반응 방정식

ethyl (5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinecarboxylate

ammonia

→

title compound

(5R)-(−)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinecarboxamide

용매

methanol

반응 조건

후처리

1. 1
   온도The resulting mixture is cooled to ambient temperature
2. 2
   농축concentrated under reduced pressure
3. 3
   기타the crude product is recrystallized from methanol

실험 절차

A mixture of ethyl (5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinecarboxylate (Step 1, 0.22 g, 0.65 mmol) in 2M ammonia in methanol (5–6 mL) is heated in a closed vial at 60° C. for approximately 1 h. The resulting mixture is cooled to ambient temperature and concentrated under reduced pressure, and the crude product is recrystallized from methanol to give the title compound, MS (ESI+) for C14H16N3O4F m/z 310 (M+H)+.

출처