반응 #81080

반응 방정식

(S)-2-Phthalimido-5,5-dimethoxypentanoic acid, methyl ester

hydrazine monohydrate

→

title product

(S)-2-Amino-5,5-dimethoxypentanoic acid, methyl ester

용매

methanol

반응 조건

후처리

1. 1
   여과The mixture was filtered
2. 2
   세척the solid was washed with methanol
3. 3
   농축The filtrate was concentrated
4. 4
   기타triturated with methylene chloride
5. 5
   여과filtered again
6. 6
   농축concentrated
7. 7
   기타dried in vacuo
8. 8
   기타to yield 1.89 g

실험 절차

(S)-2-Phthalimido-5,5-dimethoxypentanoic acid, methyl ester [prepared as described in Example 4(f), 3.35 g., 10.43 mmol.) in methanol (70 ml.) was treated with hydrazine monohydrate (531 μl., 10.95 mmol., 1.05 eq.) and the solution was stirred at room temperature for 6 days. The mixture was filtered and the solid was washed with methanol. The filtrate was concentrated, triturated with methylene chloride, filtered again, concentrated, and dried in vacuo to yield 1.89 g. of title product as a cloudy oil. TLC (10% methanol in methylene chloride) Rf =0.39.

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