반응 #809571

반응 방정식

sodium bicarbonate

octane-1,8-diol

hydrobromic acid

water

→

title compound

8-Bromooctan-1-ol

용매

cyclohexane

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   세척The organic phase was washed with saturated, aqueous sodium chloride solution
3. 3
   기타dried on sodium sulfate
4. 4
   여과filtered
5. 5
   농축concentrated by evaporation in a vacuum

실험 절차

25 g of octane-1,8-diol was boiled in 250 ml of cyclohexane with 22.6 ml of 47% aqueous hydrobromic acid for six hours in a water separator. The reaction mixture was then poured onto saturated aqueous sodium bicarbonate solution and extracted with ethyl acetate. The organic phase was washed with saturated, aqueous sodium chloride solution, dried on sodium sulfate, filtered and concentrated by evaporation in a vacuum. Column chromatography on silica gel with a mixture that consists of hexane/ethyl acetate yielded 21.6 g of the title compound as a yellowish oil.

출처