반응 #80726

반응 방정식

4,4-dimethyl-2-iso-propoxy-1,2,3,4-tetrahydro-7-[(trimethylsilyl)ethynyl]quinoline

Compound 26

4,4-dimethyl-2-iso-propoxy-1,2,3,4-tetrahydro-7-[(trimethylsilyl)ethynyl]quinoline

potassium carbonate

→

title compound

4,4-Dimethyl-2-iso-propoxy-3,4-dihydro-7-ethynylquinoline

용매

methanol

반응 조건

후처리

1. 1
   농축The reaction mixture was then concentrated in vacuo
2. 2
   workup.DISSOLUTIONthe resulting oil was dissolved in water
3. 3
   추출extracted with methylene chloride (2×)
4. 4
   건조The organic layers were dried (MgSO4)
5. 5
   여과filtered
6. 6
   농축concentrated in vacuo

실험 절차

To a solution of 0.14 g (0.45 mmol) of 4,4-dimethyl-2-iso-propoxy-1,2,3,4-tetrahydro-7-[(trimethylsilyl)ethynyl]quinoline (Compound 26) in 2.5 ml of methanol was added 0.10 g (0.72 mmol) of potassium carbonate. The reaction mixture was then stirred at room temperature for 2.5 h. The reaction mixture was then concentrated in vacuo and the resulting oil was dissolved in water and extracted with methylene chloride (2×). The organic layers were dried (MgSO4), filtered and concentrated in vacuo to give the title compound as an oil. This compound was used for the next reaction without further purification.

출처