반응 #8069

ord-7f859e611fc340788dd94777d9e88e65

반응 방정식

COC(=O)c1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
( 4 )
COC(=O)c1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
6-(2,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one
CC(C)Cn1nc(-c2ccc(F)cc2F)cc(COS(C)(=O)=O)c1=O
6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one
CCNCC
diethylamine
→
CCN(CC)Cc1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
title compound
CCN(CC)Cc1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
4-diethylaminomethyl-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

반응물

COC(=O)c1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
( 4 )
COC(=O)c1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
6-(2,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one
CC(C)Cn1nc(-c2ccc(F)cc2F)cc(COS(C)(=O)=O)c1=O
6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one
CCNCC
diethylamine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타were reacted

실험 절차

Following the procedure of Example 9 (4), 6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and diethylamine were reacted to yield the title compound as a pale yellow oil (yield: quantitative).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07087606B2uspto-grants-2006_08