반응 #80668

반응 방정식

sodium bicarbonate

1-octyloxy-2,2,6,6-tetramethyl-4-hydroxypiperidine

epichlorohydrin

1-octyloxy-2,2,6,6-tetramethyl-4-hydroxypiperidine

sodium hydroxide

→

1-Octyloxy-2,2,6,6-tetramethyl-4-(2,3-epoxypropoxy)piperidine

용매

water

반응 조건

후처리

1. 1
   기타fitted with mechanical stirrer
2. 2
   기타The organic phase is separated off
3. 3
   추출The water phase is extracted with ethyl acetate
4. 4
   세척The two organic phases are washed with sodium chloride-saturated water
5. 5
   건조dried over sodium sulfate
6. 6
   기타evaporated on a Rotavap

실험 절차

100 g (2.5 mol) of sodium hydroxide are dissolved in 100 ml of water in a 750 ml sulfonation flask fitted with mechanical stirrer, thermometer, dropping funnel and condenser. 71.9 g (0.25 mol) of 1-octyloxy-2,2,6,6-tetramethyl-4-hydroxypiperidine and 16.1 g (0.05 mol) of tetrabutylammonium bromide are added at 20° C. The mixture is warmed to 30° C. with vigorous stirring. A solution of 277.5 g (3 mol) of epichlorohydrin and 71.9 g (0.25 mol) of 1-octyloxy-2,2,6,6-tetramethyl-4-hydroxypiperidine is then added dropwise at 35° C. over the course of 75 minutes. The reaction solution is stirred at room temperature for 16 hours and poured onto 1 kg of ice and 100 g of sodium bicarbonate. The organic phase is separated off. The water phase is extracted with ethyl acetate. The two organic phases are washed with sodium chloride-saturated water, dried over sodium sulfate and evaporated on a Rotavap.

출처