반응 #806576

반응 방정식

4-vinylphenol

4-Chloromethyl-2-methylquinoline

Cs2CO3

NaI

→

2-methyl-4-(4-vinyl-phenoxymethyl)-quinoline

수율 46.8%

용매

DMSO

반응 조건

후처리

1. 1
   기타After work up, the residue was purified by flash column chromatography (40% ethyl acetate-hexanes)

실험 절차

A mixture of 4-vinylphenol (10% wt. solution in propylene glycol) (1.25 g, 1.04 mmol), 4-Chloromethyl-2-methylquinoline (0.24 g, 1.2 eq), Cs2CO3 (0.85 g, 2.5 eq) and NaI (0.20 g, 1.2 eq) in DMSO (1 ml) was stirred at rt overnight. After work up, the residue was purified by flash column chromatography (40% ethyl acetate-hexanes) to give 2-methyl-4-(4-vinyl-phenoxymethyl)-quinoline (0.134 g, 46.8%) as a white solid. MS Found: (M+H)+=276.

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