반응 #80649

반응 방정식

6-chloronicotinic acid

ethanol

dicyclohexylcarbodiimide

dimethylaminopyridine

→

title compound

Ethyl 6-chloronicotinate

용매

methylene chloride

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 2 hours
3. 3
   온도to cool
4. 4
   기타solvent removed in vacuo and residue

실험 절차

A mixture of 15.75 g (0.1 mol) 6-chloronicotinic acid, 6.9 g (0.15 mol) ethanol, 22.7 g (0.11 mol) dicyclohexylcarbodiimide and 3.7 g dimethylaminopyridine in 200 ml methylene chloride was heated at reflux for 2 hours. The mixture was allowed to cool, solvent removed in vacuo and residue subjected to flash chromatography to give the title compound as a low-melting white solid. PMR (CDCl3): & 1.44 (3H, t, J-6.2 Hz) 4.44 (2H, q, J-4.4 Hz), 7.44 (1H, d, J-8.1 Hz), 8.27 (1H, dd, J-8.1 Hz, 3 Hz), 9.02 (1H, d, J-3 Hz).

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