반응 #805297

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Title compound 471

2-chloro-3-hydrazinylpyrazine

Trimethyl orthobenzoate

→

title compound 472

수율 105.8%

8-chloro-3-phenyl-[1,2,4]triazolo[4,3-a]pyrazine

수율 105.8%

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후처리

1. 1
   온도The mixture was cooled to room temperature
2. 2
   여과the solid was filtered
3. 3
   세척washed with hexanes

실험 절차

Title compound 471 (0.8 g, 5.53 mmol) and Trimethyl orthobenzoate (5 mL, 29.1 mmol) were combined and the reaction mixture was stirred at 120° C. for 3 h. The mixture was cooled to room temperature and the solid was filtered and washed with hexanes to afford title compound 472 (1.35 g, 100%) as a beige solid. MS (m/z): 231.1 (M+H)

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