반응 #80466

반응 방정식

3-(4-fluorophenylmethyl)thiophene

CHCl3 methanol

N-iodosuccinimide

→

2-iodo-3-(4fluorophenylmethyl)thiophene

수율 95.2%

용매

CH2Cl2

반응 조건

후처리

1. 1
   추출The organic phase was extracted with saturated aqueous NaHCO3 and brine
2. 2
   건조dried over MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated in vacuo

실험 절차

To a solution of 3-(4-fluorophenylmethyl)thiophene (1.16 g, 6.04 mmol) in 1:1 CHCl3 /methanol was added N-iodosuccinimide (1.70 g, 7.53 mmol). The reaction mixture was stirred for 3 hours, and then was diluted with CH2Cl2. The organic phase was extracted with saturated aqueous NaHCO3 and brine, dried over MgSO4, filtered, and concentrated in vacuo to give 1.83 g of 2-iodo-3-(4fluorophenylmethyl)thiophene which was used without further purification.

출처