반응 #804654

반응 방정식

6-fluoro-2-(4-fluorophenyl)quinazoline-4-carboxylic acid

6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

→

compound 99

수율 50.6%

2-[[6-fluoro-2-(4-fluorophenyl)quinazolin-4-yl]carbonyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline

수율 50.6%

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실험 절차

Reaction of 6-fluoro-2-(4-fluorophenyl)quinazoline-4-carboxylic acid with 6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 99 (50.6% yield). 1H NMR (400 MHz, DMSO-d6) δ 2.80 and 3.03 (2t, 2H), 3.54 and 4.02 (2t, 2H), 3.72 and 3.74 (2s, 3H), 4.47 and 4.92 (2s, 2H), 6.65-7.27 (m, 3H), 7.40-7.48 (m, 1H), 7.62-7.82 (m, 2H), 8.05-8.10 (m, 1H), 8.20-8.39 (m, 3H); MS (ESI) m/z 432 ([M+H]+).

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