반응 #804604

반응 방정식

2-(4-(trifluoromethyl)phenyl)quinazoline-4-carboxylic acid

5,6-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

→

compound 39

수율 13.0%

2-[[2-(4-(trifluoromethyl)phenyl)quinazolin-4-yl]carbonyl]-5,6-dimethoxy-1,2,3,4-tetrahydroisoquinoline

수율 13.0%

반응 조건

실험 절차

Reaction of 2-(4-(trifluoromethyl)phenyl)quinazoline-4-carboxylic acid with 5,6-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 39 (13% yield) as a white solid. 1H NMR (300 MHz, DMSO-d6) δ 2.72 and 2.99 (2t, 2H), 3.50 and 4.04 (2t, 2H), 3.68-3.82 (4s, 6H), 4.43 and 4.94 (2s, 2H), 6.62 and 7.01 (2d, 1H), 6.81 and 7.08 (2d, 1H), 7.82-7.85 (m, 1H), 7.93-8.04 (m, 3H), 8.12-8.24 (m, 2H), 8.70-8.76 (m, 2H); MS (ESI) m/z 494 ([M+H]+).

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