반응 #804580

반응 방정식

2-(4-fluorophenyl)quinazoline-4-carboxylic acid

5-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

→

compound 10

수율 27.0%

2-[[2-(4-fluorophenyl)quinazolin-4-yl]carbonyl]-5-fluoro-1,2,3,4-tetrahydroisoquinoline

수율 27.0%

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실험 절차

Reaction of 2-(4-fluorophenyl)quinazoline-4-carboxylic acid with 5-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 10 (27.0% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ 2.88 and 3.13 (2t, 2H), 3.64 and 4.24 (2t, 2H), 4.58 and 5.14 (2s, 2H), 6.68-7.33 (m, 5H), 7.65-7.77 (m, 1H), 7.94-8.10 (m, 2H), 8.15-8.20 (m, 1H), 8.57-8.67 (m, 2H); 19F (282 MHz, DMSO-d6) δ −112.0, −121.0; MS (ESI) m/z 402 ([M+H]+).

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