반응 #804577

반응 방정식

2-(4-fluorophenyl)quinazoline-4-carboxylic acid

6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

→

compound 7

수율 23.5%

2-[[2-(4-fluorophenyl)quinazolin-4-yl]carbonyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline

수율 23.5%

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실험 절차

Reaction of 2-(4-fluorophenyl)quinazoline-4-carboxylic acid with 6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 7 (23.5% yield): 1H NMR (400 MHz, CDCl3) δ 2.87 and 3.11 (2t, 2H), 3.58 and 4.19 (2t, 2H), 3.81 and 3.84 (2s, 3H), 4.47 and 5.08 (2s, 2H), 6.68-6.90 (m, 2H), 7.20-7.25 (m, 3H), 7.57-7.66 (m, 1H), 7.93-8.06 (m, 2H), 8.19-8.21 (d, 8.65-8.71 (m, 2H); 19F (282 MHz, CDCl3) δ −109.5; MS (ESI) m/z 414 ([M+H]+).

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