반응 #804273

반응 방정식

3-(4-Bromo-phenyl)-5-methyl-2H-isoquinolin-1-one

DMF

→

4-(5-methyl-1-oxo-1,2-dihydro-isoquinolin-3-yl)-benzonitrile

수율 79.0%

반응 조건

후처리

1. 1
   기타degassed with N2
2. 2
   기타The reaction mixtures
3. 3
   기타were irradiated
4. 4
   기타a microwave (300 W, 180° C., 30 min)
5. 5
   기타The reaction mixtures
6. 6
   여과the resulting precipitate was filtered
7. 7
   세척washed with DMF and water
8. 8
   기타dried

실험 절차

3-(4-Bromo-phenyl)-5-methyl-2H-isoquinolin-1-one (200 mg, 0.64 mmol), zinc cyanide (90 mg, 0.76 mmol) and tetrakis(triphenylphosphine)palladium(0) (74 mg, 0.064 mmol) were stirred in DMF (2.1 mL) and degassed with N2. The reaction mixtures were irradiated using a microwave (300 W, 180° C., 30 min). The reaction mixtures were combined and the resulting precipitate was filtered, washed with DMF and water and dried to give 4-(5-methyl-1-oxo-1,2-dihydro-isoquinolin-3-yl)-benzonitrile as a yellowish solid (718 mg, 79%) which was used in the next step without further purification.

출처