반응 #80407

반응 방정식

urea

dimethylformamide

ethyl 4-bromo-2-hydroxyimino-3-oxobutyrate

→

title compound

수율 40.0%

Ethyl 4-Hydroxy-3-isoxazolecarboxylate

수율 40.0%

용매

water

반응 조건

후처리

1. 1
   온도cooled
2. 2
   추출the mixture was extracted with ethyl acetate
3. 3
   세척The extract was washed with dilute aqueous hydrochloric acid and with a saturated aqueous solution of sodium chloride, in that order
4. 4
   건조after which it was dried over anhydrous sodium sulfate
5. 5
   기타The solvent was then removed by distillation under reduced pressure
6. 6
   workup.ADDITIONa 1:1 by volume mixture of ethyl acetate and hexane
7. 7
   workup.ADDITIONwas added to the residue
8. 8
   기타to remove insoluble materials
9. 9
   기타The solution thus obtained
10. 10
    기타was purified by silica gel chromatography
11. 11
    세척eluted with a 1:4 by volume mixture of ethyl acetate and hexane

실험 절차

144 g of urea were added to 1 liter of a dimethylformamide solution containing 72 g of ethyl 4-bromo-2-hydroxyimino-3-oxobutyrate. The reaction solution was heated for 15 minutes at 100° C. and then cooled, after which water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was washed with dilute aqueous hydrochloric acid and with a saturated aqueous solution of sodium chloride, in that order, after which it was dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure, and a 1:1 by volume mixture of ethyl acetate and hexane was added to the residue, to remove insoluble materials. The solution thus obtained was purified by silica gel chromatography, eluted with a 1:4 by volume mixture of ethyl acetate and hexane, to give 19 g of the title compound, melting at 59°-60° C. (after recrystallization from a mixture of ethyl acetate and hexane).

출처