반응 #803710

반응 방정식

HCl

D-(−)-α-Phenylglycine

NaHCO3

methylchloroformate

→

compound 31

수율 80.0%

(R)-methoxycarbonylamino-phenyl-acetic acid

수율 80.0%

용매

tetrahydrofuran

water

반응 조건

후처리

1. 1
   농축the volatile was concentrated in vacuo
2. 2
   추출The aqueous layer was extracted with ethyl acetate
3. 3
   건조the organic layer was dried over MgSO4
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo

실험 절차

D-(−)-α-Phenylglycine (0.165 mmol) was dissolved in tetrahydrofuran (500 mL), followed by the addition of NaHCO3 (0.496 mmol) in water (500 mL), and then the addition of methylchloroformate (0.182 mmol) at room temperature. The reaction mixture was stirred at room temperature overnight. The mixture was acidified to pH=3 with HCl (1N) and the volatile was concentrated in vacuo. The aqueous layer was extracted with ethyl acetate and the organic layer was dried over MgSO4, filtered, and concentrated in vacuo to give compound 31 as a pale yellow solid in 80% yield. MS (ESI, EI+) m/z=209 (MH+).

출처