반응 #80295

반응 방정식

benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate

→

desired compound

수율 97.0%

1-Benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylic Acid

수율 97.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   여과Insoluble matters were filtered off
2. 2
   농축filtrate was concentrated under reduced pressure
3. 3
   기타The residue thereby obtained
4. 4
   세척was washed with isopropyl ether

실험 절차

1.6 g of benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate was dissolved in 50 ml of ethyl acetate, and 0.1 g of 10% palladium carbon was added thereto. Then, catalytic reduction was conducted. Insoluble matters were filtered off, and then filtrate was concentrated under reduced pressure. The residue thereby obtained was washed with isopropyl ether to obtain 1.28 g (yield: 97%) of the desired compound. mp: 113°-115° C.

출처