반응 #80282

반응 방정식

water

4-allyloxycarbonyl-5-hydroxy-2-methylbenzofuran-3-carboxylic acid

4,6-dimethoxy-2-methylsulfonylpyridine

N,N-dimethylformamide

potassium carbonate

→

desired compound

수율 98.0%

4-Allyloxycarbonyl-5-(4,6-dimethoxypyrimidin-2-yl)oxy-2-methylbenzofuran-3-carboxylic Acid

수율 98.0%

반응 조건

후처리

1. 1
   온도was heated
2. 2
   기타was returned to room temperature
3. 3
   추출extracted with ethyl acetate
4. 4
   세척The organic layer was washed with water
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   기타Crystals obtained by concentration under reduced pressure
7. 7
   세척were washed with isopropyl ether

실험 절차

A mixture comprising 54.2 g of 4-allyloxycarbonyl-5-hydroxy-2-methylbenzofuran-3-carboxylic acid, 47 g of 4,6-dimethoxy-2-methylsulfonylpyridine and 65 g of potassium carbonate in 200 ml of N,N-dimethylformamide, was heated and stirred at 70° C. for two hours. The mixture was returned to room temperature, and then the reaction solution was poured into water and extracted with ethyl acetate. The organic layer was washed with water and then dried over anhydrous magnesium sulfate. Crystals obtained by concentration under reduced pressure, were washed with isopropyl ether to obtain 79.2 g (yield: 98%) of the desired compound.

출처