반응 #80279

반응 방정식

benzyl 5-hydroxy-2-methyl-3-methoxycarbonylbenzofuran-4-carboxylate

4,6-dimethoxy-2-methylsulfonyl-1,3,5-triazine

potassium carbonate

→

desired compound

수율 109.7%

Benzyl 5-(4,6-Dimethoxy-1,3,5-triazin-2-yl)oxy-2-methyl-3-methoxycarbonylbenzofuran-4-carboxylate

수율 109.7%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   온도was heated
2. 2
   기타was returned to room temperature
3. 3
   추출extracted with ethyl acetate
4. 4
   세척The organic layer was washed with water
5. 5
   건조dried over anhydrous sodium sulfate
6. 6
   농축Then, it was concentrated under reduced pressure
7. 7
   세척the obtained solid was thoroughly washed with ethanol

실험 절차

A mixture comprising 2 g of benzyl 5-hydroxy-2-methyl-3-methoxycarbonylbenzofuran-4-carboxylate, 1 g of 4,6-dimethoxy-2-methylsulfonyl-1,3,5-triazine and 1 g of potassium carbonate in 20 ml of N,N-dimethylformamide, was heated and stirred at 70° C. for two hours. The mixture was returned to room temperature, poured into ice water and extracted with ethyl acetate. The organic layer was washed with water and then dried over anhydrous sodium sulfate. Then, it was concentrated under reduced pressure, and the obtained solid was thoroughly washed with ethanol to obtain 2.4 g (yield: 86%) of the desired compound.

출처