반응 #80271

반응 방정식

water

4-formyl-5-hydroxy-3-methylbenzothiophene

4,6-dimethoxy-2-methylsulfonylpyrimidine

potassium carbonate

→

desired compound

수율 86.0%

5-(4,6-dimethoxypyrimidin-2-yl)oxy-4-formyl-3-methylbenzothiophene

수율 86.0%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   온도was heated
2. 2
   기타was returned to room temperature
3. 3
   추출extracted with ethyl acetate
4. 4
   세척The organic layer was washed with water
5. 5
   건조dried over anhydrous sodium sulfate
6. 6
   농축Then, it was concentrated under reduced pressure
7. 7
   기타the oily substance thereby obtained
8. 8
   기타was purified by silica gel column chromatography (n-hexane/ethyl acetate=10/1)

실험 절차

A mixture comprising 2.1 g of 4-formyl-5-hydroxy-3-methylbenzothiophene, 2.4 g of 4,6-dimethoxy-2-methylsulfonylpyrimidine and 1.8 g of potassium carbonate in 30 ml of N,N-dimethylformamide, was heated and stirred at 70° C. for 3 hours. The mixture was returned to room temperature, then poured into water and extracted with ethyl acetate. The organic layer was washed with water and then dried over anhydrous sodium sulfate. Then, it was concentrated under reduced pressure, and the oily substance thereby obtained was purified by silica gel column chromatography (n-hexane/ethyl acetate=10/1) to obtain 3.1 g (yield: 86%) of the desired compound.

출처