반응 #80270

반응 방정식

N-[2-((phenoxycarbonyl)oxy)ethyl]-N,N-dimethylamine

phenyl chloroacetate

→

N-2-((Phenoxycarbonyl)oxy)ethyl-N-((phenoxycarbonyl)methyl)-N,N-dimethyl-ammonium Chloride

용매

acetonitrile

반응 조건

후처리

1. 1
   기타To a 250 ml three-necked round-bottomed flask fitted with a reflux condenser, magnetic stirrer
2. 2
   workup.ADDITIONinternal thermometer, addition funnel, and argon inlet
3. 3
   workup.ADDITIONAfter addition
4. 4
   온도the mixture is heated
5. 5
   온도to reflux for 3 h
6. 6
   기타The cooled mixture is triturated with ether (500 ml)
7. 7
   기타A white solid, 23.15 g (51%) is isolated
8. 8
   기타to give 9

실험 절차

To a 250 ml three-necked round-bottomed flask fitted with a reflux condenser, magnetic stirrer, internal thermometer, addition funnel, and argon inlet are added N-[2-((phenoxycarbonyl)oxy)ethyl]-N,N-dimethylamine (25.00 g, 0.120 mol), acetonitrile (100 ml), and phenyl chloroacetate (20.38 g, 0.120 mol) over 5 min. After addition is complete, the mixture is heated to reflux for 3 h. The cooled mixture is triturated with ether (500 ml). A white solid, 23.15 g (51%) is isolated to give 9.

출처