반응 #80259

반응 방정식

hydrogen peroxide

isatin

sulfuric acid

→

isatoic acid anhydride

용매

acetic acid

반응 조건

후처리

1. 1
   workup.ADDITIONwere charged in a 500 ml two-neck flask
2. 2
   workup.STIRRINGthe mixture was stirred at 60° to 65° C. for one hour
3. 3
   온도a half and then cooled
4. 4
   여과The deposit was filtered
5. 5
   세척washed with water
6. 6
   기타dried under vacuum

실험 절차

The isatin derivative (70 g) obtained in the above item (i), 200 ml of acetic acid and 0.8 ml of concentrated sulfuric acid were charged in a 500 ml two-neck flask and the mixture was stirred at room temperature. Then, 50 ml of 30% hydrogen peroxide was added dropwise to the mixture. After the completion of dropping, the mixture was stirred at 60° to 65° C. for one hour and a half and then cooled. The deposit was filtered, washed with water and dried under vacuum to give 35 g of a derivative of isatoic acid anhydride represented by the following formula (20): ##STR24##

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