반응 #80258

반응 방정식

chloral

hydroxylammonium chloride

hydrochloride

aniline

isatin

→

isonitrosoacetanilide

반응 조건

후처리

1. 1
   기타as shown in the following reaction scheme
2. 2
   기타an aqueous solution obtained
3. 3
   기타is reacted for 0.5 to 2 hours
4. 4
   온도with heating at 70° to 110° C.

실험 절차

The isatin derivative (9) can be synthesized, for example, as shown in the following reaction scheme. That is, an aqueous solution obtained by adding chloral and hydroxylammonium chloride to hydrochloride of an aniline derivative (10) as a starting material is reacted for 0.5 to 2 hours with heating at 70° to 110° C. to give an isonitrosoacetanilide derivative, and this product is cyclized with concentrated sulfuric acid and hydrolyzed to give an isatin derivative (9). ##STR10## wherein R1A to R1D are as defined above.

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