반응 #8023

반응 방정식

Water

2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one

potassium phthalimide

→

title compound

수율 81.8%

2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-phthalimidomethyl-2H-pyridazin-3-one

수율 81.8%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   workup.STIRRINGAfter stirring
2. 2
   기타precipitated crystals
3. 3
   여과were collected by filtration
4. 4
   기타dried in air
5. 5
   기타recrystallized from chloroform-hexane

실험 절차

To a solution of 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one (220 mg, 0.57 mmol) in N,N-dimethylformamide (5 mL) was added potassium phthalimide (160 mg, 0.87 mmol), and the mixture was stirred at 80° C. for 2 hours. Water (30 mL) was added to the reaction mixture. After stirring under cooling over ice water, precipitated crystals were collected by filtration, dried in air, and recrystallized from chloroform-hexane to yield the title compound as colorless needles (202 mg, 81.0%).

출처