반응 #80124

ord-e7ff8e30833145d7a201030d65ddec20

반응 방정식

Cc1cc(C(=O)O)ccn1.Cl
2-methyl-isonicotinic acid hydrochloride
COCCN(C)c1ccc(OC)c2nc(N)sc12
4-methoxy-N7-(2-methoxy-ethyl)-N7-methyl-benzothiazole-2,7-diamine
CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HATU
→
COCCN(C)c1ccc(OC)c2nc(NC(=O)c3ccnc(C)c3)sc12
N-{4-Methoxy-7-[(2-methoxy-ethyl)-methyl-amino]-benzothiazol-2-yl}-2-methyl-isonicotinamide

반응물

Cc1cc(C(=O)O)ccn1.Cl
2-methyl-isonicotinic acid hydrochloride
—
N-diethylisopropylamine
COCCN(C)c1ccc(OC)c2nc(N)sc12
4-methoxy-N7-(2-methoxy-ethyl)-N7-methyl-benzothiazole-2,7-diamine
CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HATU

시약

없음

용매

C1CCOC1
THF
C1COCCO1
dioxane
CN(C)C=O
DMF

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

From 2-methyl-isonicotinic acid hydrochloride, HATU and N-diethylisopropylamine in THF, then treatment with 4-methoxy-N7-(2-methoxy-ethyl)-N7-methyl-benzothiazole-2,7-diamine in dioxane and DMF. ES-MS m/e (%): 387 (M+H+, 100).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06713499B2uspto-grants-2004_03