반응 #80036

반응 방정식

H2O

4-bromo-3-tert-butylphenol

Intermediate 104

4-bromo-3-tert-butylphenol

imidazole

chloro-triisopropylsilane

→

title compound

(4-Bromo-3-tert-butyl-phenoxy)-triisopropyl-silane

용매

DMF

반응 조건

후처리

1. 1
   추출extracted with EtOAc
2. 2
   세척The combined organic layers were washed with H2O and saturated aqueous NaCl
3. 3
   건조before being dried (MgSO4)
4. 4
   농축concentrated under reduced pressure

실험 절차

To a solution of 4-bromo-3-tert-butylphenol (Intermediate 104, 1.17 g, 5.10 mmols) and imidazole (520.0 mg, 7.65 mmols) in 10 mL DMF was added chloro-triisopropylsilane (1.18 g, 6.10 mmols). After stirring overnight at room temperature the solution was diluted wirth H2O and extracted with EtOAc. The combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound, 1.80 g (92%), was isolated by column chromatography (0-1.5% EtOAc-hexanes) as a colorless oil.

출처