반응 #799897

ord-0e9a216bdf2249be8a68e5b06db44190

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

6-[5-(1-Benzyloxycarbonyl-1-methyl-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester is synthesized according to the procedure of Suzuki Coupling Method VI using 2-(5-bromo-pyridin-3-yl)-2-methyl-propionic acid benzyl ester and crude 6-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (Intermediate G).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09181272B2uspto-grants-2015_11