반응 #799864

반응 방정식

2-(5-bromo-pyridin-3-yl)-2-methyl-propionic acid ethyl ester

sodium borohydride

→

2-(5-bromo-pyridin-3-yl)-2-methyl-propan-1-ol

수율 31.9%

용매

MeOH

반응 조건

후처리

1. 1
   온도The resulting mixture is heated
2. 2
   온도to reflux for 5 h
3. 3
   농축concentrated
4. 4
   세척then is washed with water
5. 5
   추출extracted with DCM
6. 6
   건조The combined organic layers are dried (Na2SO4)
7. 7
   농축concentrated
8. 8
   기타purified by silica gel column

실험 절차

To a solution of 2-(5-bromo-pyridin-3-yl)-2-methyl-propionic acid ethyl ester (2.4 g, 0.009 mol) in MeOH (30 mL) is added sodium borohydride (1.7 g, 0.044 mol). The resulting mixture is heated to reflux for 5 h. The reaction is cooled to room temperature and concentrated then is washed with water and extracted with DCM. The combined organic layers are dried (Na2SO4), concentrated and purified by silica gel column to obtain 2-(5-bromo-pyridin-3-yl)-2-methyl-propan-1-ol (661 mg).

출처