반응 #799649

반응 방정식

LiAlH4

2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione

→

title compound

수율 25.4%

2-benzyloctahydro-1H-pyrrolo[3,4-c]pyridine

수율 25.4%

용매

THF

반응 조건

후처리

1. 1
   온도The reaction mixture was refluxed for 6 h under N2
2. 2
   기타quenched with ice-water
3. 3
   여과filtered
4. 4
   농축The filtrate was concentrated in vacuo

실험 절차

To a solution of LiAlH4 (1.00 g) in THF was added slowly 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione (2.00 g) at 0° C. The reaction mixture was refluxed for 6 h under N2, and cooled to rt, quenched with ice-water and filtered. The filtrate was concentrated in vacuo to give the title compound as yellow oil (0.45 g, 25%). The crude product was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 217.2 (M+1).

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