반응 #799599

반응 방정식

5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione

LiAlH4

→

title compound

수율 61.0%

2-benzyloctahydropyrrolo[3,4-c]pyrrole

수율 61.0%

용매

THF

반응 조건

후처리

1. 1
   온도The reaction mixture was heated
2. 2
   온도to reflux for 4 h
3. 3
   기타quenched with water
4. 4
   추출the mixture was extracted with EtOAc
5. 5
   건조The organic phase was dried over anhydrous Na2SO4 for 1 h
6. 6
   여과filtered
7. 7
   농축The filtrate was concentrated in vacuo
8. 8
   기타the residue was chromatographed with a silica gel column (eluting agent: 200:30:1 (v/v) DCM/MeOH/NH3H2O)

실험 절차

To a suspension of 5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione (3.88 g) in THF (80 mL) at −5° C. was added LiAlH4 (1.92 g) slowly. The reaction mixture was heated to reflux for 4 h, and then quenched with water, the mixture was extracted with EtOAc. The organic phase was dried over anhydrous Na2SO4 for 1 h and filtered. The filtrate was concentrated in vacuo and the residue was chromatographed with a silica gel column (eluting agent: 200:30:1 (v/v) DCM/MeOH/NH3H2O) to give the title compound as oil (2.07 g, 61.00%).

출처