반응 #7990

반응 방정식

HCl

Aluminum chloride

1-chloro-3-fluoro-2-methoxybenzene

hexanoyl chloride

→

1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone

반응 조건

후처리

1. 1
   온도The mixture warmed
2. 2
   기타partitioned between EtOAc (40 mL) and ice cold water (40 mL)
3. 3
   세척The EtOAc layer was washed with brine (30 mL)
4. 4
   건조dried over MgSO4
5. 5
   여과filtered
6. 6
   기타evaporated under vacuum

실험 절차

Aluminum chloride (1.16 g, 8.72 mmol) was added to a stirred mixture of 1-chloro-3-fluoro-2-methoxybenzene (1.00 mL, 8.72 mmol) and hexanoyl chloride (1.47 mL, 10.46 mmol) at room temperature. The mixture warmed and HCl evolution occurred. The resulting mixture was stirred at room temperature for 67 hours and then partitioned between EtOAc (40 mL) and ice cold water (40 mL). The EtOAc layer was washed with brine (30 mL), dried over MgSO4, filtered, and evaporated under vacuum to yield crude 1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone as an oil.

출처