반응 #7979
ord-194006f950674b50a93e6edc19549752
반응 방정식
반응 조건
온도
80°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도After cooling
- 2기타the mixture was partitioned between EtOAc (20 mL) and water (20 mL)
- 3세척The organic phase was washed with brine (20 mL)
- 4건조dried over MgSO4
- 5여과filtered
- 6기타evaporated under vacuum
실험 절차
The product from step 1 in ethanol (1.0 mL), water (0.2 mL) and aqueous 2N HCl (0.2 mL) was stirred and heated in an oil bath at 80° C. for 40 minutes. After cooling, the mixture was partitioned between EtOAc (20 mL) and water (20 mL). The organic phase was washed with brine (20 mL), dried over MgSO4, filtered, and evaporated under vacuum to provide 4-acetyl-9a-butyl-8-chloro-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one (54 mg) as an oil.