반응 #79763

반응 방정식

2-fluorobenzonitrile

4-bromophenol

potassium carbonate

→

2-(4-bromophenoxy)benzonitrile

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도was heated
2. 2
   workup.WAITto stand overnight at ambient temperature
3. 3
   기타partitioned between ethyl acetate and water
4. 4
   기타The organic layer was separated
5. 5
   세척washed
6. 6
   기타dried
7. 7
   기타evaporated
8. 8
   기타to give an oil which
9. 9
   기타The solid was triturated with petroleum ether b.p. 40-60° C.
10. 10
    여과filtered

실험 절차

A mixture of 2-fluorobenzonitrile (28.8 g), 4-bromophenol (36.9 g), potassium carbonate (58.9 g) and dimethylformamide (30 ml) was heated with stirring under nitrogen at 120° C. for 5 hours. The mixture was allowed to stand overnight at ambient temperature and then partitioned between ethyl acetate and water. The organic layer was separated, washed, dried and evaporated to give an oil which solidified on standing. The solid was triturated with petroleum ether b.p. 40-60° C. and filtered to give 2-(4-bromophenoxy)benzonitrile.

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