반응 #796994

반응 방정식

5-(bromomethyl)-2-(2-fluoro-5-methoxyphenyl)-3-neopentylpyridine

ethyl 3-cyclopropyl-3-(2-hydroxypyridin-4-yl)propanoate

→

title compound

수율 22.4%

ethyl 3-cyclopropyl-3-(2-((6-(2-fluoro-5-methoxyphenyl)-5-neopentylpyridin-3-yl)methoxy)pyridin-4-yl)propanoate

수율 22.4%

용매

toluene

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 3 hr
3. 3
   여과filtered
4. 4
   기타The solvent in the filtrate was evaporated under reduced pressure
5. 5
   기타the residue was purified by silica gel column chromatography (ethyl acetate/hexane)

실험 절차

A mixture of 5-(bromomethyl)-2-(2-fluoro-5-methoxyphenyl)-3-neopentylpyridine (88 mg), ethyl 3-cyclopropyl-3-(2-hydroxypyridin-4-yl)propanoate (62 mg), silver carbonate (72.6 mg) and toluene (2.0 mL) was heated under reflux for 3 hr. The reaction mixture was cooled to room temperature and filtered. The solvent in the filtrate was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (28 mg) as an orange oil.

출처