반응 #79569

반응 방정식

N-cyclohexylaniline

benzyl isothiocyanate

→

(cyclohexylphenylamino)-N-benzylthiocarboxamide

용매

acetonitrile

반응 조건

후처리

1. 1
   기타The solvent was removed under reduced pressure
2. 2
   기타the residue purified on preparative silica gel plates

실험 절차

To a solution of N-cyclohexylaniline (0.1 ml, 0.57 mmol) in acetonitrile (4 ml) was added a catalytic amount of 4-(dimethylamino)pyridine (5 mg, 0.04 mmol). To this mixture was added benzyl isothiocyanate (0.11 ml, 0.83 mmol) dropwise, and the mixture was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, and the residue purified on preparative silica gel plates, developing with 20% ethyl acetate/hexanes, to furnish (cyclohexylphenylamino)-N-benzylthiocarboxamide as a white solid, (M+1)=324.8.

출처