반응 #795348

반응 방정식

1-(2-methyl-1-(tritylamino)propan-2-yl)thiourea

4,8-dibromo-3,4-dihydro-2Hbenzo[b]oxepin-5-one

→

N2-(8-bromo-4,5-dihydrothiazolo[4,5-d]benzo[b]oxepin-2-yl)-2-methylpropane-1,2-diamine hydrobromide

수율 68.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도under reflux for 18 hours

실험 절차

Following the Example 356, 1-(2-methyl-1-(tritylamino)propan-2-yl)thiourea was reacted with 4,8-dibromo-3,4-dihydro-2Hbenzo[b]oxepin-5-one in ethanol under reflux for 18 hours to give N2-(8-bromo-4,5-dihydrothiazolo[4,5-d]benzo[b]oxepin-2-yl)-2-methylpropane-1,2-diamine hydrobromide. Yield 68%. MS(ESI+): 368.0

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