반응 #794571

반응 방정식

Intermediate 47

Benzyl (cis-3-hydroxycyclobutyl)carbamate

p-toluenesulfonyl chloride

triethylamine

→

crude product

수율 123.1%

cis-3-(((benzyloxy)carbonyl)amino)cyclobutyl 4-methylbenzenesulfonate

수율 123.1%

용매

DCM

DCM

반응 조건

후처리

1. 1
   기타Reaction mixture
2. 2
   세척washed with saturated NaHCO3 solution
3. 3
   건조Organic layer was dried over sodium sulfate

실험 절차

A solution of Intermediate 47 (0.67 g, 3.03 mmol), p-toluenesulfonyl chloride (Sigma Aldrich, 1.155 g, 6.06 mmol), triethylamine (Aldrich, 1.688 ml. 12.11 mmol) in DCM (6.06 ml) was stirred at room temperature overnight. Reaction mixture was diluted with DCM and washed with saturated NaHCO3 solution. Organic layer was dried over sodium sulfate to provide 1.4 g crude product upon rotovap. Material was advanced to next step before further purification.

출처